Grants and Contributions:

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Title:

Lipid signalling in yeast

Agreement Number:

RGPIN

Agreement Value:

$381,000.00

Agreement Date:

May 10, 2017 -

Organization:

Natural Sciences and Engineering Research Council of Canada

Location:

British Columbia, CA

Reference Number:

GC-2017-Q1-02914

Agreement Type:

Grant

Report Type:

Grants and Contributions

Additional Information:

Grant or Award spanning more than one fiscal year. (2017-2018 to 2022-2023)

Recipient's Legal Name:

Loewen, Christopher (The University of British Columbia)

Program:

Discovery Grants Program - Individual

Program Purpose:

The general objective of this research proposal is to define roles for lipids in the regulation of cellular metabolism. This research will enhance our understanding of basic fundamental mechanisms of lipid-mediated intracellular signalling and will identify new metabolic regulatory mechanisms important to all organisms. Presently, very little is known about the functions of lipids in these processes. The model organism Saccharomyces cerevisiae has proven to be an excellent model system for investigating the roles of lipids in cells because of the ease of genetic manipulation in this organism and the highly conserved nature of these pathways. Thus, many of the groundbreaking discoveries made in yeast have been highly applicable to higher organisms including humans. We will use sophisticated high-throughput yeast genetics to define cellular pathways that regulate phospholipid metabolism on a genome-wide scale. These studies will identify important new factors involved in the global control of lipid synthesis and uncover fundamental novel mechanisms of lipid-based signal transduction.