Grants and Contributions:

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Title:

Polymer conjugation to the Feldan Shuttle to reduce blood protein adsorption and interaction with cell membranes

Agreement Number:

EGP

Agreement Value:

$25,000.00

Agreement Date:

Mar 7, 2018 -

Organization:

Natural Sciences and Engineering Research Council of Canada

Location:

Quebec, CA

Reference Number:

GC-2017-Q4-00648

Agreement Type:

Grant

Report Type:

Grants and Contributions

Additional Information:

Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019).

Recipient's Legal Name:

Gauthier, Marc (Institut national de la recherche scientifique)

Program:

Engage Grants for universities

Program Purpose:

For a medication to be effective, it must be able to reach its target. One of the greatest challenges for manyx000D
drugs is that their targets lie inside cells. Indeed, cells are surrounded by a membrane that keeps manyx000D
molecules out - including drugs. Even the most powerful drug will be ineffective if it cannot reach its target.x000D
Feldan Therapeutics Inc. has developed a technology, termed the Feldan shuttle, which facilitates the transferx000D
of several types of drugs into cells. They now face a technological challenge, associated with the stability of thex000D
Shuttle in blood, that they cannot resolve themselves. As such, Feldan Therapeutics Inc. has approached Profx000D
Marc A Gauthier of the INRS to investigate structural alterations to the Shuttle and the influence of thesex000D
modifications on: 1) the physical nature of complexes formed with therapeutic cargo, and 2) their interactionx000D
with blood proteins.