Grants and Contributions

The Exploration stream of the NFRF program supports high risk, high reward and interdisciplinary research that is not easily supported through funding opportunities currently offered by the three agencies. It seeks to inspire projects that bring disciplines together beyond traditional disciplinary or common interdisciplinary approaches by research teams with the capacity to explore something new, which might fail but has the potential for significant impact. Exploration grants aim to have a variety of types of impacts, some of which might be social, economic, scientific, artistic or cultural. This is not an exhaustive list; other types of impacts are also recognized.

Many older Canadians wish to age in place, but bathroom accessibility is a major barrier due to space, layout, and retrofit challenges. To date, there is limited guidance for the functional space and configuration requirements to support bathroom maneuvers by individuals who use assistive devices, including 1) WhMD users and 2) people who require a caregiver or support person for bathing or toileting. This study will provide essential evidence to inform discussion for the National Building Code of Canada. Findings from
this work will remove barriers for older adults, while also considering the need for minimum requirements that would allow some accessibility to be provided in tight spaces that are common in the real-world. The widespread uptake of evidence into design practice will be supported by engaging the technical committees developing requirements for the National Building Code of Canada (NBC) in this area.

Patients with advanced cutaneous squamous cell carcinoma (cSCC) who are not eligible for or have failed to respond to anti-PD1 immunotherapy have few treatment options. Epidermal growth factor receptor (EGFR) directed chimeric antigen receptor -T cell (CAR-T) therapy is a promising strategy; however, off-target toxicity remains a major obstacle due to expression in healthy tissues. To address this concern, the use of intratumoural (IT) administration of NRC’s novel nanobody-based EGFR CAR-T will be evaluated in the pre-clinical model of cSCC. The aims of the study will be to determine the dosage required for tumour control and evaluate the trafficking and functional T-cell phenotypes in IT administration. It is expected that IT administration will lead to substantially fewer CAR-T cells in all biological compartments than traditional intravenous (IV) administration, and that direct injection of cells will result in different T-cell populations within the tumour.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

The Exploration stream of the NFRF program supports high risk, high reward and interdisciplinary research that is not easily supported through funding opportunities currently offered by the three agencies. It seeks to inspire projects that bring disciplines together beyond traditional disciplinary or common interdisciplinary approaches by research teams with the capacity to explore something new, which might fail but has the potential for significant impact. Exploration grants aim to have a variety of types of impacts, some of which might be social, economic, scientific, artistic or cultural. This is not an exhaustive list; other types of impacts are also recognized.

Through collaboration with the NRC’s Aging-in-Place Research Program and
KITE Research Institute-University Health Network, this study aims to fill this
evidence gap by evaluating the applied grab bar loads during sit-to-stand
transfers.

To strengthen responses to drug and substance use issues in Canada.

To strengthen responses to drug and substance use issues in Canada.

The program Advancing Accessibility Standards Research (The Program) funds the project. The Program funds research projects. The projects try to find, take away and stop obstacles to accessibility. This research will help to guide accessibility standards in the future.

The Exploration stream of the NFRF program supports high risk, high reward and interdisciplinary research that is not easily supported through funding opportunities currently offered by the three agencies. It seeks to inspire projects that bring disciplines together beyond traditional disciplinary or common interdisciplinary approaches by research teams with the capacity to explore something new, which might fail but has the potential for significant impact. Exploration grants aim to have a variety of types of impacts, some of which might be social, economic, scientific, artistic or cultural. This is not an exhaustive list; other types of impacts are also recognized.