Grants and Contributions:
Title:
Precision targeted RNA loaded exosomes for in vivo gene-based therapeutics
Agreement Number:
962726
Agreement Value:
$221,364.00
Agreement Date:
Jan 1, 2021 - Apr 30, 2024
Description:
Potent and specific gene therapies used to treat patients have been limited by the lack of delivery vehicles to introduce them into specific cells. Evidence suggests that vesicles naturally produced by cells, called extracellular vesicles, can be highly efficient delivery vehicles. The Gibbings lab has uncovered technology allowing loading of RNA-based gene therapies, such as silencing RNAs, into extracellular vesicles. To optimize the therapeutic use of these extracellular vesicles, this Project will use single-domain or monoclonal antibodies developed by the NRC against novel cell-specific markers to target extracellular vesicles to specific cell types or tissues in vivo, including into immune cells and across the blood brain barrier. This will enhance the precision targeting of extracellular vesicles to deliver RNA-based gene therapies.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2020-2021-Q3-962805
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Recipient Type:
Academia
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 485 days.
Amendment Date
May 5, 2023
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa–Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: