Amendments for: 172-2020-2021-Q3-962805

Agreement Value: $221,364.00
Agreement: Precision targeted RNA loaded exosomes for in vivo gene-based therapeutics (962726). Jan 1, 2021 - Feb 28, 2025
Description:

Potent and specific gene therapies used to treat patients have been limited by the lack of delivery vehicles to introduce them into specific cells. Evidence suggests that vesicles naturally produced by cells, called extracellular vesicles, can be highly efficient delivery vehicles. The Gibbings lab has uncovered technology allowing loading of RNA-based gene therapies, such as silencing RNAs, into extracellular vesicles. To optimize the therapeutic use of these extracellular vesicles, this Project will use single-domain or monoclonal antibodies developed by the NRC against novel cell-specific markers to target extracellular vesicles to specific cell types or tissues in vivo, including into immune cells and across the blood brain barrier. This will enhance the precision targeting of extracellular vesicles to deliver RNA-based gene therapies.

Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.

Organization: National Research Council Canada
Recipient: University of Ottawa (Academia)
Location: Ottawa, Ontario, CA K1N 6N5
Type: Grant
Additional Information:

This agreement has been amended 2 time(s). The end date of this agreement has been modified by 303 days.

Federal Riding Name: Ottawa–Vanier (35078)
Program Name: Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives

Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.

NAICS Code: 541710 - R&D in the physical, engineering and life sciences

Agreement Value:
Organization: National Research Council Canada
Recipient: -
Type: -
Additional Information:

This agreement has been amended 2 time(s). The end date of this agreement has been modified by 303 days.

NAICS Code: 541710 - R&D in the physical, engineering and life sciences

Agreement Value:
Organization: National Research Council Canada
Recipient: -
Type: -
Additional Information:

This agreement has been amended 1 time(s). The end date of this agreement has been modified by 485 days.

NAICS Code: 541710

Agreement Value: $221,364.00
Agreement: Precision targeted RNA loaded exosomes for in vivo gene-based therapeutics (962805). Jan 1, 2021 - Dec 31, 2022
Description:

Potent and specific gene therapies used to treat patients have been limited by the lack of delivery vehicles to introduce them into specific cells. Evidence suggests that vesicles naturally produced by cells, called extracellular vesicles, can be highly efficient delivery vehicles. The Gibbings lab has uncovered technology allowing loading of RNA-based gene therapies, such as silencing RNAs, into extracellular vesicles. To optimize the therapeutic use of these extracellular vesicles, this Project will use single-domain or monoclonal antibodies developed by the NRC against novel cell-specific markers to target extracellular vesicles to specific cell types or tissues in vivo, including into immune cells and across the blood brain barrier. This will enhance the precision targeting of extracellular vesicles to deliver RNA-based gene therapies.

Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.

Organization: National Research Council Canada
Recipient: University of Ottawa (Academia)
Location: Ottawa, Ontario, CA K1N 6N5
Type: Grant
Federal Riding Name: Ottawa–Vanier (35078)
Program Name: Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives

Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.

NAICS Code: 541742